Longevity Peptides

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These peptides offer diverse mechanisms of action for promoting longevity, targeting various pathways involved in mitochondrial function, oxidative stress, DNA repair, immune function, and sleep regulation.  

• Mechanism of Action: Epithalon is a synthetic peptide derived from the pineal gland. It regulates the production of melatonin and other hormones involved in aging and longevity, while also promoting antioxidant activity and DNA repair.

• Impact on Longevity: Epithalon has been shown to extend lifespan and improve overall healthspan in animal studies. It promotes DNA repair, reduces oxidative stress, and regulates hormone levels associated with aging, making it a promising candidate for promoting longevity and healthy aging.

• Mechanism of Action: SS-31 is a mitochondrial-targeted peptide that improves mitochondrial function and reduces oxidative stress. It enhances cellular energy production and protects against age-related mitochondrial dysfunction.

• Impact on Longevity: SS-31 has demonstrated efficacy in extending lifespan and improving healthspan in animal models of aging. By preserving mitochondrial function and reducing oxidative damage, it may promote longevity and delay age-related decline in cellular function.

• Mechanism of Action: MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide that regulates metabolism and energy balance. It activates AMP-activated protein kinase (AMPK) and improves mitochondrial function, which may contribute to longevity.

• Impact on Longevity: MOTS-C has been shown to extend lifespan and improve metabolic health in animal studies. By enhancing mitochondrial function and metabolic regulation, it may promote longevity and delay age-related diseases associated with metabolic dysfunction.

• Mechanism of Action: Rapamycin is a macrolide antibiotic with immunosuppressant and anti-cancer properties. It inhibits the mechanistic target of rapamycin (mTOR) pathway, which regulates cellular growth, proliferation, and senescence.

• Impact on Longevity: Rapamycin has been shown to extend lifespan and delay age-related decline in various animal models. By inhibiting the mTOR pathway, it may slow down the aging process, reduce age-related diseases, and promote longevity.

• Mechanism of Action: NAD+ is a coenzyme involved in various cellular processes, including energy metabolism, DNA repair, and gene expression. Its levels decline with age, leading to mitochondrial dysfunction and cellular senescence.

• Impact on Longevity: NAD+ supplementation has been shown to extend lifespan and improve healthspan in animal studies. By restoring NAD+ levels, it may enhance mitochondrial function, promote DNA repair, and delay age-related decline, thereby promoting longevity.

• Mechanism of Action: DSIP is a neuropeptide that regulates sleep and stress response. It promotes deep sleep and relaxation, which are essential for overall health and longevity.

• Impact on Longevity: DSIP supplementation has been shown to improve sleep quality and reduce stress in animal studies. By promoting restorative sleep and reducing stress, it may contribute to longevity and overall well-being.

• Mechanism of Action: Kisspeptin is a peptide hormone that regulates reproductive function and gonadotropin-releasing hormone (GnRH) secretion. It plays a crucial role in fertility and sexual maturation.

• Impact on Longevity: Kisspeptin has been implicated in the regulation of aging and longevity through its effects on reproductive function and metabolism. However, its direct impact on longevity remains to be fully elucidated.

• Mechanism of Action: Thymosin Alpha 1 is a peptide derived from the thymus gland. It modulates immune function by stimulating the production of T cells, enhancing T cell maturation, and promoting immune system balance.

• Impact on Longevity: Thymosin Alpha 1 may indirectly promote longevity by supporting immune function and reducing the risk of infection and age-related diseases. However, more research is needed to understand its direct impact on longevity.

• Mechanism of Action: GHK-Cu is a peptide complex containing copper, a trace mineral essential for various physiological processes. It promotes collagen production, angiogenesis, and tissue remodeling, while also exhibiting antioxidant and anti-inflammatory properties.

• Impact on Longevity: GHK-Cu has been shown to enhance wound healing, tissue regeneration, and overall skin health. While its direct impact on longevity is not well-studied, its ability to promote tissue repair and reduce inflammation may indirectly contribute to longevity.