Tirzepatide Research Protocols
Materials Needed:
- Tirzepatide in dry powder (5 mg) in a 3 ml vial
- 1 ml of Bacteriostatic (BAC) water
- 1 CC (1 ml) insulin syringe
Reconstitution:
- Withdrawal 1ML of BAC Water and slowly insert into Peptide vial.
- Gently and slowly swirl till dissolved.
- Allow to sit, away form direct light, for 5 minutes.
After reconstitution, you have a 5 mg/1 ml solution of Tirzepatide. The next step is to calculate the required volume for your intended dose.
Given the reconstitution, 1 ml of the solution contains 5 mg of Tirzepatide. Therefore, the concentration is 5 mg/ml. Here is how you measure different doses using the insulin syringe (which is typically marked in units, where 100 units = 1 ml):
2.5 mg Dose:
- Draw 50 units on the insulin syringe.
5 mg Dose:
- Draw 100 units (the entre vial) into the insulin syringe.
Dose Escalation:
- 2.5 mg once weekly: For the first 3-6 weeks.
- 5 mg once weekly: For the subsequent 3-6 weeks.
- 8.5 mg once weekly: For the subsequent 3-6 weeks
- 12 mg once weekly: For the subsequent 3-6 weeks
Maintenance Dose:
- 5 mg every 3 days: This is the maintenance dose after the dose escalation phase once desired weight loss has been achieved.
Guidelines
- Injection Sites: Tirzepatide is administered subcutaneously in the abdomen, thigh, or upper arm. The injection site should be rotated each week.
- Timing: The injections should be taken on the same day each week, at any time of the day, with or without meals.
- Missed Dose: If a dose is missed, it should be administered as soon as possible within 5 days after the missed dose. If more than 5 days have passed, the missed dose should be skipped, and the next dose should be taken on the regular schedule.
