Tirzepatide Research Protocols

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 Materials Needed: 

• Tirzepatide in dry powder (5 mg) in a 3 ml vial
• 1 ml of Bacteriostatic (BAC) water
• 1 CC (1 ml) insulin syringe

Reconstitution: 

• Withdrawal 1ML of BAC Water and slowly insert into Peptide vial. 
• Gently and slowly swirl till dissolved. 
• Allow to sit, away form direct light, for 5 minutes. 

After reconstitution, you have a 5 mg/1 ml solution of Tirzepatide. The next step is to calculate the required volume for your intended dose. 

Given the reconstitution, 1 ml of the solution contains 5 mg of Tirzepatide. Therefore, the concentration is 5 mg/ml. Here is how you measure different doses using the insulin syringe (which is typically marked in units, where 100 units = 1 ml):

2.5 mg Dose:

• Draw 50 units on the insulin syringe.

5 mg Dose:

• Draw 100 units (the entre vial) into the insulin syringe.

Dose Escalation:

• 2.5 mg once weekly: For the first 3-6 weeks.
• 5 mg once weekly: For the subsequent 3-6 weeks.
• 8.5 mg once weekly: For the subsequent 3-6 weeks
• 12 mg once weekly: For the subsequent 3-6 weeks

Maintenance Dose:

• 5 mg every 3 days: This is the maintenance dose after the dose escalation phase once desired weight loss has been achieved. 

Guidelines

• Injection Sites: Tirzepatide is administered subcutaneously in the abdomen, thigh, or upper arm. The injection site should be rotated each week.
• Timing: The injections should be taken on the same day each week, at any time of the day, with or without meals.
• Missed Dose: If a dose is missed, it should be administered as soon as possible within 5 days after the missed dose. If more than 5 days have passed, the missed dose should be skipped, and the next dose should be taken on the regular schedule.