Weight Loss Peptides

---

Semaglutide

• Mechanism of Action: Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of endogenous GLP-1. It regulates blood sugar levels by stimulating insulin secretion and inhibiting glucagon release. Additionally, semaglutide slows gastric emptying and promotes satiety, leading to reduced food intake.

• Impact on Fat Loss: Clinical trials have shown that semaglutide can lead to significant weight loss in individuals with obesity. In the STEP trials, participants treated with semaglutide achieved greater weight loss compared to those receiving placebo, making it an effective option for fat loss management.

• Mechanism of Action: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Like semaglutide, it regulates blood sugar levels, promotes insulin secretion, and reduces food intake by delaying gastric emptying and increasing satiety.

• Impact on Fat Loss: Clinical trials have demonstrated that tirzepatide leads to substantial weight loss in individuals with obesity and type 2 diabetes. Its dual agonism of GIP and GLP-1 rec

• Mechanism of Action: AOD-9604 is a peptide fragment derived from human growth hormone (hGH). It targets adipose tissue and stimulates the breakdown of stored fat into energy, primarily through lipolysis, without affecting muscle mass.

• Impact on Fat Loss: Preclinical and early clinical studies have suggested that AOD-9604 can promote fat loss, particularly in stubborn areas such as the abdomen and thighs. Its selective action on fat cells makes it a promising option for targeted fat reduction.

• Mechanism of Action: Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) that increases the levels of neurotransmitters involved in appetite regulation and energy expenditure. It suppresses appetite and boosts metabolism, leading to weight loss.

• Impact on Fat Loss: Clinical trials have shown that tesofensine leads to significant weight loss by reducing food intake and increasing energy expenditure. Its ability to modulate neurotransmitter levels makes it effective for fat loss management.

• Mechanism of Action: Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce and release growth hormone (GH). It primarily targets abdominal fat and reduces visceral adiposity.

• Impact on Fat Loss: Clinical trials have demonstrated that tesamorelin can reduce abdominal fat in individuals with HIV-associated lipodystrophy. Its ability to specifically target visceral fat makes it a valuable tool for fat loss in certain populations.

• Mechanism of Action: Melanotan 2 is a synthetic analogue of the melanocortin peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It activates melanocortin receptors in the brain, leading to appetite suppression and increased energy expenditure.

• Impact on Fat Loss: While primarily known for its tanning effects, melanotan 2 has also been studied for its potential role in weight loss. Animal studies suggest that it may reduce food intake and body weight, but further research is needed to determine its efficacy and safety in humans for fat loss.

• Mechanism of Action: Insulin-like growth factor 1 (IGF-1) LR3 is a modified version of IGF-1 with an extended half-life. It promotes muscle growth and fat loss by activating insulin-like growth factor receptors and enhancing protein synthesis.

• Impact on Fat Loss: While IGF-1 LR3 is primarily known for its anabolic effects on muscle tissue, some studies suggest that it may also promote fat loss by increasing metabolism and reducing adipose tissue. However, its use for fat loss purposes remains controversial and requires further investigation.

• Mechanism of Action: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide that regulates metabolism and energy balance. It activates AMP-activated protein kinase (AMPK) and improves mitochondrial function, leading to increased fat oxidation and energy expenditure.

• Impact on Fat Loss: Preclinical studies have shown that MOTS-c supplementation can lead to reductions in body weight and fat mass in animal models. Its ability to enhance metabolic health makes it a promising candidate for fat loss interventions.

• Mechanism of Action: 5-Amino-1MQ is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in the regulation of tryptophan metabolism and immune response. By blocking IDO1 activity, it modulates inflammation and improves metabolic health.

• Impact on Fat Loss: Animal studies have suggested that 5-Amino-1MQ supplementation can lead to reductions in body weight and adiposity, likely through its anti-inflammatory and metabolic effects. However, further research is needed to elucidate its potential for fat loss in humans.

These peptides offer diverse mechanisms of action for fat loss, targeting various aspects of metabolism, appetite regulation, and energy expenditure. While many show promise in preclinical and clinical studies, it's essential to consult with a healthcare professional before using any peptide for fat loss purposes.