CJC-1295 + Ipamorelin Dosage Protocol (With & Without DAC)
CJC-1295 and Ipamorelin are the most widely researched GH secretagogue stack — two peptides that work on different receptors and produce synergistically greater GH release when used together. This guide covers dosing for both the No DAC and With DAC variants of CJC-1295, stacking protocols, injection frequency, and the timing principles that determine how effectively GH is released.
Research use only. Neither CJC-1295 nor Ipamorelin is FDA-approved for general human use. Dosing ranges are derived from animal studies and research community practice. Consult a medical professional before any administration.
CJC-1295 No DAC (Mod GRF 1-29)
- • Half-life: ~30 minutes
- • Produces a clean, short-duration GH pulse
- • Must be injected 2–3x daily
- • Preferred for stacking with Ipamorelin (pulse-matched)
- • More physiologically natural pulse pattern
CJC-1295 With DAC
- • Half-life: ~8 days (DAC = Drug Affinity Complex)
- • Provides a constant background GHRH signal
- • Dosed once or twice per week
- • Blunts GH pulsatility — may reduce some benefits
- • Simpler schedule; preferred by some practitioners
Which to choose: No DAC is generally preferred for research purposes because it maintains pulsatile GH release — the pattern the pituitary naturally uses. With DAC provides convenience but continuously elevated GHRH may reduce natural GH pulsatility over time.
Dosage Protocols
CJC-1295 No DAC + Ipamorelin Stack
CJC-1295 No DAC dose
100–200 mcg per injection
Ipamorelin dose
100–300 mcg per injection
Frequency
2–3x daily
Timing
Before bed (primary) + morning fasted
Cycle
8–12 weeks on, 4 weeks off
The most popular GH secretagogue stack. Both compounds are short-acting — they're injected together at the same time and produce a synergistic GH pulse by activating two different receptors simultaneously.
CJC-1295 With DAC (solo or with Ipamorelin)
CJC-1295 With DAC dose
1–2 mg per injection
Ipamorelin dose (if stacking)
100–300 mcg per injection
CJC With DAC frequency
Once or twice per week
Ipamorelin frequency (if stacking)
2–3x daily (separate schedule)
Cycle
8–12 weeks on, 4 weeks off
CJC-1295 With DAC provides a sustained background GHRH signal throughout the week. If combined with Ipamorelin, the GHRP is still dosed daily to trigger pulses on top of the constant GHRH elevation.
Pre-sleep is optimal
The largest natural GH pulse occurs 45–90 minutes after sleep onset. Injecting GH secretagogues before bed amplifies this natural pulse — the most efficient timing for GH optimization.
Fasted state matters
Elevated insulin (from eating) significantly blunts GH release. Inject at least 90 minutes after your last meal. This applies to both pre-sleep and morning doses.
Morning fasted dosing
A second injection in the morning fasted state (before breakfast) is a common addition for researchers seeking multiple daily GH pulses. Insulin is naturally low after overnight fast.
Pre-workout (less common)
Some researchers inject before training. GH has lipolytic and anabolic effects that could theoretically benefit training. However, the pre-sleep pulse optimization is generally considered more important.
CJC-1295 (a GHRH analogue) and Ipamorelin (a GHRP/ghrelin mimetic) work on two completely separate receptor systems. CJC-1295 activates the GHRH receptor on pituitary somatotrophs, priming them to release GH. Ipamorelin activates the ghrelin receptor (GHS-R1a), which independently triggers a GH pulse.
When both signals arrive simultaneously, the resulting GH release is significantly greater than either compound alone — this is genuine receptor-level synergy, not additive overlap. Animal studies and clinical observation consistently show the stack produces a GH pulse 3–5x larger than either compound in isolation.
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