CMS 121
A novel neuroprotective compound that targets fatty acid synthase (FASN) to reduce lipid peroxidation and protect against age-related cognitive decline.
Common Dosage
Research phase (preclinical)
Category
Nootropic
- Neuroprotection
- Anti-aging for brain
- Cognitive preservation
- Lipid peroxidation reduction
CMS 121 was developed by the Bhanu Bharat group at the Salk Institute as part of a research program identifying compounds that protect against age-related neurodegeneration. It is a derivative of fisetin (a natural polyphenol) engineered for improved neuroprotective potency. The compound targets fatty acid synthase (FASN) as part of its mechanism, reducing toxic lipid accumulation in aging neurons. It represents an example of precision medicinal chemistry applied to cognitive aging.
CMS 121 inhibits fatty acid synthase (FASN) in neurons, reducing the accumulation of lipid peroxidation byproducts that increase with aging and oxidative stress. Lipid peroxidation in neuronal membranes is a major contributor to age-related synaptic dysfunction and neurodegeneration. By reducing this process, CMS 121 preserves mitochondrial function and synaptic integrity. It also modulates the mTOR pathway toward autophagy — cellular cleanup processes that decline with age.
- Age-related cognitive decline prevention
- Alzheimer's disease preclinical research
- Lipid peroxidation reduction in neural tissue
- Neuroprotection following oxidative stress
Aged Mouse Cognitive Rescue
CMS 121-treated aged mice showed significant improvements in memory and learning tests, associated with reduced markers of lipid peroxidation and improved mitochondrial function in hippocampal tissue. The effect was comparable to caloric restriction in some parameters.
- Entirely preclinical — no human data whatsoever
- FASN inhibition has broad metabolic implications beyond neurology — cancer metabolism, liver lipid synthesis, and reproductive tissue effects
- No established dosing, safety profile, or optimal delivery route for humans
- Research-grade versions are not characterized
- Unknown (Research compound)